APECED: is this a model for failure of T cell and B cell tolerance?

@inproceedings{Kluger2012APECEDIT,
  title={APECED: is this a model for failure of T cell and B cell tolerance?},
  author={Nicolas Kluger and Annamari Ranki and Kai Krohn},
  booktitle={Front. Immun.},
  year={2012}
}
In APECED, the key abnormality is in the T cell defect that may lead to tissue destruction chiefly in endocrine organs. Besides, APECED is characterized by high-titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED, mainly chronic mucocutaneous candidiasis, and linked to antibodies against Th17 cells effector molecules, IL-17 and IL-22. On the other hand, the same antibodies, together with antibodies against type I… CONTINUE READING

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Besides , APECED is characterized by high - titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED , mainly chronic mucocutaneous candidiasis , and linked to antibodies against Th17 cells effector molecules , IL-17 and IL-22 .
Besides , APECED is characterized by high - titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED , mainly chronic mucocutaneous candidiasis , and linked to antibodies against Th17 cells effector molecules , IL-17 and IL-22 .
Besides , APECED is characterized by high - titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED , mainly chronic mucocutaneous candidiasis , and linked to antibodies against Th17 cells effector molecules , IL-17 and IL-22 .
Besides , APECED is characterized by high - titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED , mainly chronic mucocutaneous candidiasis , and linked to antibodies against Th17 cells effector molecules , IL-17 and IL-22 .
On the other hand , the same antibodies , together with antibodies against type I interferons may prevent the patients from other immunological diseases , such as psoriasis and systemic lupus erythematous .
On the other hand , the same antibodies , together with antibodies against type I interferons may prevent the patients from other immunological diseases , such as psoriasis and systemic lupus erythematous .
Besides , APECED is characterized by high - titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED , mainly chronic mucocutaneous candidiasis , and linked to antibodies against Th17 cells effector molecules , IL-17 and IL-22 .
Besides , APECED is characterized by high - titer antibodies against a wide variety of cytokines that could partly be responsible for the clinical symptoms during APECED , mainly chronic mucocutaneous candidiasis , and linked to antibodies against Th17 cells effector molecules , IL-17 and IL-22 .
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