APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

@article{Willis2013APE2IR,
  title={APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.},
  author={Jeremy Willis and Yogin Patel and Barry L. Lentz and Shan Yan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 26},
  pages={10592-7}
}
The base excision repair pathway is largely responsible for the repair of oxidative stress-induced DNA damage. However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress at the molecular level. Here, we provide evidence showing that hydrogen peroxide (H2O2) triggers checkpoint kinase 1 (Chk1) phosphorylation in an ATR [ataxia-telangiectasia mutated (ATM) and Rad3-related]-dependent but ATM-independent manner in Xenopus egg extracts. A base excision repair protein… CONTINUE READING
24 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…