APE/Ref-1 and the mammalian response to genotoxic stress.

  title={APE/Ref-1 and the mammalian response to genotoxic stress.},
  author={Gerhard Fritz and Sabine Gr{\"o}sch and Maja Tomici{\'c} and Bernd Kaina},
  volume={193 1-2},
Human apurinic/apyrimidinic endonuclease/redox factor-1 (hAPE/Ref-1) is a multifunctional protein involved in the repair of DNA damaged by oxidative or alkylating compounds as well as in the regulation of stress inducible transcription factors such as AP-1, NF-kappaB, HIF-1 and p53. With respect to transcriptional regulation, both redox dependent and independent mechanisms have been described. APE/Ref-1 also acts as a transcriptional repressor. Recent data indicate that APE/Ref-1 negatively… CONTINUE READING

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