APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

Abstract

Homeostatic plasticity is crucial for maintaining neuronal output by counteracting unrestrained changes in synaptic strength. Chronic elevation of synaptic activity by bicuculline reduces the amplitude of miniature excitatory postsynaptic currents (mEPSCs), but the underlying mechanisms of this effect remain unclear. We found that activation of EphA4… (More)
DOI: 10.1038/nn.2715

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