APC polymorphisms and the risk of colorectal neoplasia: a HuGE review and meta-analysis.

@article{Liang2013APCPA,
  title={APC polymorphisms and the risk of colorectal neoplasia: a HuGE review and meta-analysis.},
  author={Jing Liang and Chunqing Lin and Fulan Hu and Fan Wang and Lin Zhu and Xiaoping Yao and Yibaina Wang and Yashuang Zhao},
  journal={American journal of epidemiology},
  year={2013},
  volume={177 11},
  pages={
          1169-79
        }
}
Adenomatous polyposis coli gene (APC) polymorphisms may influence the risk for colorectal neoplasia. However, results thus far have been inconclusive. We performed a systematic literature search of the Medline, Embase, Cochrane Collaboration, and HuGE databases and reviewed the references of pertinent articles through May 2012. Odds ratios with 95% confidence intervals were used to estimate the association between 3 APC polymorphisms (D1822V, E1317Q, and I1307K) and colorectal neoplasia. In… CONTINUE READING

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