APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.

@article{Abal2007APCIA,
  title={APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.},
  author={Miguel Abal and Ant{\`o}nia Obrador-Hevia and Klaus Janssen and Laura Casadom{\'e} and Mireia Men{\'e}ndez and Sabrina Carpentier and Emmanuel Barillot and Mechthild Wagner and Wilhelm J. Ansorge and Gabriela Moeslein and Hafida Fsihi and Vladimir Bezrookove and J. Dargallo Revent{\'o}s and Daniel Louvard and G. Capella and Sylvie Robine},
  journal={Gastroenterology},
  year={2007},
  volume={132 7},
  pages={
          2448-58
        }
}
BACKGROUND & AIMS Chromosomal instability, a hallmark of most colorectal cancers, has been related to altered chromosome segregation and the consequent deficit in genetic integrity. A role for the tumor suppressor gene APC has been proposed in colorectal cancer that leads to compromised chromosome segregation even though the molecular mechanism is not yet understood. Here, we tackled the genetic basis for the contribution of APC to chromosomal instability in familial adenomatous polyposis and… CONTINUE READING

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