APC and its modifiers in colon cancer.

@article{Kwong2009APCAI,
  title={APC and its modifiers in colon cancer.},
  author={Lawrence N. Kwong and W. Franklin Dove},
  journal={Advances in experimental medicine and biology},
  year={2009},
  volume={656},
  pages={
          85-106
        }
}
Colon cancer closely follows the paradigm of a single "gatekeeper gene." Mutations inactivating the APC (adenomatous polyposis coli) gene are found in approximately 80% of all human colon tumors and heterozygosity for such mutations produces an autosomal dominant colon cancer predisposition in humans and in murine models. However, this tight association between a single genotype and phenotype belies a complex association of genetic and epigenetic factors that together generate the broad… CONTINUE READING

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