APC: the plot thickens.

@article{Bienz1999APCTP,
  title={APC: the plot thickens.},
  author={Mariann Bienz},
  journal={Current opinion in genetics & development},
  year={1999},
  volume={9 5},
  pages={595-603}
}
  • Mariann Bienz
  • Published 1999 in Current opinion in genetics & development
Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive. 

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