APC: the plot thickens.

  title={APC: the plot thickens.},
  author={Mariann Bienz},
  journal={Current opinion in genetics & development},
  volume={9 5},
  • Mariann Bienz
  • Published 1999 in Current opinion in genetics & development
Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive. 

From This Paper

Topics from this paper.
29 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 29 extracted citations

Similar Papers

Loading similar papers…