APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle.

@article{NarbonneReveau2008APCCFzrCdh1PC,
  title={APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle.},
  author={Karine Narbonne-Reveau and Stefania Senger and Margit Pal and Anabel Herr and Helena E Richardson and Maki Asano and P{\'e}ter De{\'a}k and Mary A Lilly},
  journal={Development},
  year={2008},
  volume={135 8},
  pages={
          1451-61
        }
}
The endocycle is a commonly observed variant cell cycle in which cells undergo repeated rounds of DNA replication with no intervening mitosis. How the cell cycle machinery is modified to transform a mitotic cycle into endocycle has long been a matter of interest. In both plants and animals, the transition from the mitotic cycle to the endocycle requires Fzr/Cdh1, a positive regulator of the Anaphase-Promoting Complex/Cyclosome (APC/C). However, because many of its targets are transcriptionally… CONTINUE READING
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