APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.

@article{Qiao2010APCCCdh1FC,
  title={APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.},
  author={Xinxian Qiao and Liyong Zhang and Armin M. Gamper and Takeo Fujita and Yong Wan},
  journal={Cell cycle},
  year={2010},
  volume={9 19},
  pages={3904-12}
}
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two WD-40 domain proteins, Cdc20 and Cdh1. While APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. In the past several years, numerous biochemical and mouse genetic studies have greatly attracted our… CONTINUE READING