APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.


Human cells have evolved elaborate mechanisms for responding to DNA damage to maintain genome stability and prevent carcinogenesis. For instance, the cell cycle can be arrested at different stages to allow time for DNA repair. The APC/C(C) (dh1) ubiquitin ligase mainly regulates mitotic exit but is also implicated in the DNA damage-induced G2 arrest… (More)
DOI: 10.15252/embj.201489017


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