AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

@article{Hayashi2012AP2AC,
  title={AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.},
  author={Hisamitsu Hayashi and Kaori Inamura and Kensuke Aida and Sotaro Naoi and Reiko Horikawa and Hironori Nagasaka and Tomozumi Takatani and Tamio Fukushima and Asami Hattori and Takashi Yabuki and Ikuo Horii and Yuichi Sugiyama},
  journal={Hepatology},
  year={2012},
  volume={55 6},
  pages={1889-900}
}
UNLABELLED The bile salt export pump (BSEP) mediates the biliary excretion of bile salts and its dysfunction induces intrahepatic cholestasis. Reduced canalicular expression of BSEP resulting from the promotion of its internalization is one of the causes of this disease state. However, the molecular mechanism underlying BSEP internalization from the… CONTINUE READING