AP1 is essential for generation of autophagosomes from the trans-Golgi network.

@article{Guo2012AP1IE,
  title={AP1 is essential for generation of autophagosomes from the trans-Golgi network.},
  author={Yajuan Guo and Chunmei Chang and Rui Huang and Bo Liu and Lan Bao and Wei Liu},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 7},
  pages={1706-15}
}
Despite recent advances in understanding the functions of autophagy in developmental and pathological conditions, the underlying mechanism of where and how autophagosomal structures acquire membrane remains enigmatic. Here, we provide evidence that post-Golgi membrane traffic plays a crucial role in autophagosome formation. Increased secretion of constitutive cargo from the trans-Golgi network (TGN) to the plasma membrane induced the formation of microtubule-associated protein light chain 3… CONTINUE READING

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