AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

@inproceedings{Nilsen2012APEI,
  title={AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe},
  author={Line B. Nilsen and Rune Johansen Forstr{\o}m and Magnar Bj{\o}r{\aa}s and Ingrun Alseth},
  booktitle={Nucleic acids research},
  year={2012}
}
Abasic (AP) sites are formed spontaneously and are inevitably intermediates during base excision repair of DNA base damages. AP sites are both mutagenic and cytotoxic and key enzymes for their removal are AP endonucleases. However, AP endonuclease independent repair initiated by DNA glycosylases performing β,δ-elimination cleavage of the AP sites has been described in mammalian cells. Here, we describe another AP endonuclease independent repair pathway for removal of AP sites in… CONTINUE READING

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