AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites

@article{Dyrkheeva2016APE1,
  title={AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites},
  author={Nadezhda S Dyrkheeva and Natalia A. Lebedeva and Olga I Lavrik},
  journal={Biochemistry (Moscow)},
  year={2016},
  volume={81},
  pages={951-967}
}
Human apurinic/apyrimidinic endonuclease 1 (APE1) is one of the key participants in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5′-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3′-hydroxyl group and a 5′-deoxyribose phosphate moiety. APE1 exhibits 3′-phosphodiesterase, 3′-5′-exonuclease, and 3-phosphatase activities. APE1 was also identified as a redox factor (Ref-1). In this review, data on the role of APE1 in the DNA repair process and in… CONTINUE READING
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