AP-3 Directs the Intracellular Trafficking of HIV-1 Gag and Plays a Key Role in Particle Assembly

@article{Dong2005AP3DT,
  title={AP-3 Directs the Intracellular Trafficking of HIV-1 Gag and Plays a Key Role in Particle Assembly},
  author={Xinhong Dong and Hua Li and Aaron Derdowski and Lingmei Ding and Atuhani Burnett and Xuemin Chen and Timothy R. Peters and Terence S Dermody and Elvin A Woodruff and Jaang-Jiun Wang and Paul Spearman},
  journal={Cell},
  year={2005},
  volume={120},
  pages={663-674}
}
Gag proteins direct the process of retroviral particle assembly and form the major protein constituents of the viral core. The matrix region of the HIV-1 Gag polyprotein plays a critical role in the transport of Gag to the plasma membrane assembly site. Recent evidence indicates that Gag trafficking to late endosomal compartments, including multivesicular bodies, occurs prior to viral particle budding from the plasma membrane. Here we demonstrate that the matrix region of HIV-1 Gag interacts… CONTINUE READING