AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development.

@article{Lim2005AP2alphaSR,
  title={AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development.},
  author={Jae Hyung Lim and Anne B. Booker and Ting Luo and Trevor Williams and Yasuhide Furuta and Oleg V Lagutin and Guillermo Oliver and T. D. Sargent and Justin R. Fallon},
  journal={Human molecular genetics},
  year={2005},
  volume={14 14},
  pages={2027-34}
}
Fragile X syndrome (FXS) is almost always caused by silencing of the FMR1 gene. The defects observed in FXS indicate that the normal FMR1 gene has a range of functions and plays a particularly prominent role during development. However, the mechanisms regulating FMR1 expression in vivo are not known. Here, we have tested the role of the transcription factor AP-2alpha in regulating Fmr1 expression. Chromatin immunoprecipitation showed that AP-2alpha associates with the Fmr1 promoter in vivo… CONTINUE READING

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