AP-2-dependent internalization of potassium channel Kir2.3 is driven by a novel di-hydrophobic signal.


The localization and density of Kir2.3 channels are influenced by the balance between PDZ protein interaction at the cell surface and routing into the endocytic pathway. Here, we explore mechanisms by which the Kir2.3 channel is directed into the endocytic pathway. We found that Kir2.3 channels are constitutively internalized from the cell surface in a… (More)
DOI: 10.1074/jbc.M709756200


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