AP-1A and AP-3A lysosomal sorting functions.

  title={AP-1A and AP-3A lysosomal sorting functions.},
  author={Uwe Reusch and Olaf Bernhard and Ulrich Koszinowski and Peter Schu},
  volume={3 10},
Heterotetrameric adaptor-protein complexes AP-1A and AP-3A mediate protein sorting in post-Golgi vesicular transport. AP-1A and AP-3A have been localized to the trans-Golgi network, indicating a function in protein sorting at this compartment. AP-3A appears to mediate trans-Golgi network-to-lysosome and also endosome-to-lysosome protein sorting. AP-1A is thought to be required for both trans-Golgi network-to-endosome transport and endosome-to-trans-Golgi network transport. However, the recent… CONTINUE READING

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