AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells.

@article{Watanabe2003AP1MR,
  title={AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells.},
  author={Mariko Watanabe and Yuji Ogawa and Kinji Ito and Masaaki Higashihara and Marshall Edward Kadin and Lawrence J. Abraham and Toshiki Watanabe and Ryouichi Horie},
  journal={The American journal of pathology},
  year={2003},
  volume={163 2},
  pages={633-41}
}
Overexpression of CD30 is the hallmark of Hodgkin and Reed-Sternberg (H-RS) cells and drives constitutive nuclear factor-kappaB activation that is the molecular basis for the pathophysiology of Hodgkin's lymphoma. Transcription of the CD30 gene is controlled by the core promoter that is driven by Sp-1 and the microsatellite sequences (MSs) that represses core promoter activity. To understand the mechanism(s) of CD30 overexpression in H-RS cells, we structurally and functionally characterized… CONTINUE READING

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JunB expression was detected in H - RS cells in vitro and in vivo , but not in reactive cells or tumor cells of non - Hodgkin 's lymphoma of diffuse large B - cell type .
JunB expression was detected in H - RS cells in vitro and in vivo , but not in reactive cells or tumor cells of non - Hodgkin 's lymphoma of diffuse large B - cell type .
JunB expression was detected in H - RS cells in vitro and in vivo , but not in reactive cells or tumor cells of non - Hodgkin 's lymphoma of diffuse large B - cell type .
JunB expression was detected in H - RS cells in vitro and in vivo , but not in reactive cells or tumor cells of non - Hodgkin 's lymphoma of diffuse large B - cell type .
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