AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.

Abstract

It has been proposed that sustained ICOS expression in chronic inflammatory immune conditions, such as autoimmunity and allergy, contributes to symptom exacerbation. Therefore modulation of ICOS gene expression could be a potential therapeutic strategy for such immune diseases. However, the precise molecular mechanisms controlling ICOS gene expression… (More)
DOI: 10.1002/eji.201141897

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