AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila

@article{Sanyal2002AP1FU,
  title={AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila},
  author={Subhabrata Sanyal and D. Sandstrom and Charles A Hoeffer and Mani Ramaswami},
  journal={Nature},
  year={2002},
  volume={416},
  pages={870-874}
}
Activity-regulated gene expression mediates many aspects of neural plasticity, including long-term memory. In the prevailing view, patterned synaptic activity causes kinase-mediated activation of the transcription factor cyclic AMP response-element-binding protein, CREB. Together with appropriate cofactors, CREB then transcriptionally induces a group of ‘immediate–early’ transcription factors and, eventually, effector proteins that establish or consolidate synaptic change. Here, using a… CONTINUE READING
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