AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity

Abstract

The AP-1 transcription factor is a central component of signal transduction pathways in many cells, although the exact role of AP-1 in controlling cell growth and malignant transformation is unknown. We have previously shown that AP-1 complexes are activated by peptide and steroid growth factors in both normal and malignant breast cells, and that blocking… (More)
DOI: 10.1038/sj.onc.1207889

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@article{Liu2004AP1BI, title={AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity}, author={Yongmin Liu and Chunhua Lu and Qiang Shen and Debbie Mu{\~n}oz-Medellin and Heetae Kim and Powel H. Brown}, journal={Oncogene}, year={2004}, volume={23}, pages={8238-8246} }