AP-1/jun is required for early Xenopus development and mediates mesoderm induction by fibroblast growth factor but not by activin.

@article{Dong1996AP1junIR,
  title={AP-1/jun is required for early Xenopus development and mediates mesoderm induction by fibroblast growth factor but not by activin.},
  author={Ziming Dong and Rosa Xu and Jung-Hwan Kim and Song Zhan and Winnie Ma and Nancy H. Colburn and Hsiang-fu Kung},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 17},
  pages={9942-6}
}
In Xenopus, normal mesoderm formation depends on signaling through the fibroblast growth factor (FGF) tyrosine kinase receptor. An important signaling pathway from receptor tyrosine kinases involves Ras/Raf/MAP kinase. However, the downstream pathway that occurs in the nucleus to finally trigger gene expression for mesoderm formation remains unknown. We report here that a high level of activator protein-1 (AP-1)-dependent transcriptional activity is detected during the early development of… CONTINUE READING
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