AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata

@inproceedings{Shen2013AP1IRF3TA,
  title={AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata},
  author={Ting E Shen and Woo Seok Yang and Young-Su Yi and Gi-Ho Sung and Man Hee Rhee and Haryoung Poo and Mi-Yeon Kim and K W Kim and Jong Heon Kim and Jae Youl Cho},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2013}
}
Andrographolide (AG) is an abundant component of plants of the genus Andrographis and has a number of beneficial properties including neuroprotective, anticancer, anti-inflammatory, and antidiabetic effects. Despite numerous pharmacological studies, the precise mechanism of AG is still ambiguous. Thus, in the present study, we investigated the molecular mechanisms of AG and its target proteins as they pertain to anti-inflammatory responses. AG suppressed the production of nitric oxide (NO) and… CONTINUE READING