ANTIMALARIAL EFFECTS OF RIBOFLAVIN DEFICIENCY

@article{Dutta1985ANTIMALARIALEO,
  title={ANTIMALARIAL EFFECTS OF RIBOFLAVIN DEFICIENCY},
  author={P. Dutta and J. Pinto and R. Rivlin},
  journal={The Lancet},
  year={1985},
  volume={326},
  pages={1040-1043}
}
La carence en riboflavine modifie l'activite de plusieurs enzymes du metabolisme intermediaire, ce qui a pour effet une protection vis-a-vis du paludisme. L'addition de riboflavine aux milieux de culture inhibe l'activite in vitro de plusieurs medicaments sur P. falciparum. Plusieurs produits qui induisent chez l'animal des carences en riboflavine ont une activite antipaludique 
Glutathion reductase activity and its relation with riboflavin levels measured by methemoglobin reduction by cystamine in patients with malaria
La plupart des amazoniens indigenes qui n'ont jamais presente de paludisme et les malades indigenes de la region amazonienne (75%) presentaient une reduction de la glutathion reductase alors que laExpand
Inhibition of Riboflavin Metabolism in Cardiac and Skeletal Muscles of Rats by Quinacrine and Tetracycline
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Enhanced uptake and metabolism of riboflavin in erythrocytes infected with Plasmodium falciparum.
  • P. Dutta
  • Biology, Medicine
  • The Journal of protozoology
  • 1991
TLDR
The studies indicate that the requirement for riboflavin may be greater in the parasite than in the host erythrocyte, and this increased rib oflavin requirement may be due to rapid multiplication, higher metabolic rate, and extreme vulnerability to oxidative stress of malaria parasites compared with that of host ERYthrocytes. Expand
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Adriamycin-induced increase in serum aldosterone levels: effects in riboflavin-sufficient and riboflavin-deficient rats.
TLDR
It is suggested that flavins play a decisive role in regulating the levels of aldosterone and raise the possibility that the adriamycin-induced increase in serum ald testosterone may be part of the pathogenetic mechanisms of cardiovascular toxicity and overall muscular weakness. Expand
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TLDR
It is concluded that the selection of drugs for further studies in vivo cannot solely be based on positive results in vitro, and in vitro screening for anti‐malarial activity in drugs approved for human use for other indications is discussed in the light of the results. Expand
Increased plasma lipid peroxidation in riboflavin-deficient, malaria-infected children.
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It is proposed that riboflavin deficiency restricts regeneration of reduced glutathione making the parasitized erythrocytes more vulnerable to destructive lipid peroxidation and increasing plasma lipid hydroperoxides. Expand
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TLDR
Findings indicate that chlorpromazine is a riboflavin antagonist and inhibits effects of thyroxine upon rib oflavin metabolism. Expand
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TLDR
The antioxidative and enzymeprotective effects of flavins were discussed in connection with lipid metabolism in vivo and riboflavin showed a similar effect, but the effect was less than that of rib oflavin-tetrabutyrate. Expand
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Two possible mechanisms by which riboflavin deficiency might influence the growth and multiplication of P. berghei are discussed, namely, a depression of reticulocytosis and an effect on the synthesis of reduced glutathione in the parasite or red blood cell. Expand
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Increases in cytochrome P-450 and cytochrome b5 and a decrease in NADPH-cytochrome c (P-450) reductase were generally brought about by feeding the riboflavin-deficient diet to young rats (50-120 gExpand
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