• Corpus ID: 16055047

ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA L EAF

@inproceedings{AmrutiaJay2011ANTICONVULSANTAO,
  title={ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA L EAF},
  author={N AmrutiaJay and Lala Minaxi and Moses Rajan Semuel},
  year={2011}
}
Moringa oleifera which is commonly kn own as drumstick tree has been used for its nutrition value and extensively used as a CNS depressant traditionally. Present work has been carried out to evaluate the anticonvulsant activity of methanolic extract of M. oleifera leaves against pentylenetetra zole (PTZ) and maximal electroshock (MES) induce d convulsions at different dose level (200 mg/kg and 400 mg/kg i.p.). Diazepam and phenytoin (5mg/kg i.p. and 25mg/kg i.p., respectively) were used as a… 

Tables from this paper

ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA IN SWISS ALBINO MICE
TLDR
The data suggests that the ethanolic extracts Moringa oleifera leaves may produce its anticonvulsant effect via different mechanisms since it prevented the hind limb extension induced by MES, decreased the duration of convulsions produced by PTZ and abolished status epilepticus in pilocarpine induced seizures.
Evaluation of anti-epileptic activity of fresh fruit juice of Moringa oleifera against maximal electroshock (M.E.S) and Picrotoxin (PTX) induced convulsions in mice
TLDR
Fresh fruit juice of Moringa oleifera at the dose of 50ml/kg p.o shows anticonvulsant activity against Maximal electroshock and Picrotoxin induced convulsion in mice.
Analgesic effect of ethanolic leaf extract of moringa oleifera on albino mice
TLDR
The ethanolic leaf extract of Moringa oleifera exhibited analgesic activity in both models showing its both central and peripheral analgesic actions.
Phytochemical and neurotoxicity evaluation of methanolic leaf-extract of Moringa oleifera
TLDR
Phytochemical screening and quantitative analysis showed that the methanol leaf-extract of M. oleifera has no neurotoxic effect even at high doses; and so, it very safe for use in the treatment regimes.
Evaluation of liver protective activity of Moringa oleifera bark extract in paracetamol induced hepatotoxicity in rats
TLDR
The biochemical parameters provide evidence that the ethanolic extract of of Moringa oleifera bark has shown hepatoprotective activity.
Phytochemistry and Pharmacology of Moringa oleifera Lam
TLDR
The present review discusses the phytochemical composition, medicinal uses & pharmacological activity of this plant.
Drumstick (Moringa oleifera): A Miracle Tree for its Nutritional and Pharmaceutic Properties
TLDR
The genus Moringa includes 13 species distributed in subHimalayan, ranges of India, Sri Lanka, North Eastern and South Western Africa, Madagascar and Arabia, and is called as “Miracle Tree” because of its high nutritional value and medicinal uses.
Phytopharmacological potential of the natural gift Moringa oleifera Lam and its therapeutic application: An overview
TLDR
The results of bioactivity study results revealed that different extracts of Moringa oleifera showed notable therapeutic activities, and the phytochemical composition and various pharmacological activities were explored to arouse public consciousness about the nutritional and medicinal value of this “miracle tree” in favor of humanity.
...
1
2
...

References

SHOWING 1-10 OF 22 REFERENCES
ANTICONVULSANT EFFECT OF SOUR ORANGE FLOWERS EXTRACT IN EXPERIMENTAL PENTYLENETETRAZOL-INDUCED SEIZURES IN RAT
TLDR
The results showed that, when the animals were pretreated via IP route, the extract of the flowers could attenuate PTZ-induced seizures in rats, evidenced by the significantly longer latencies of the appearance of writhing reflex.
Central nervous system depressant action of flavonoid glycosides.
Evaluation of ethanolic extract of Moringa oleifera for wound healing, anti-inflammatory and antioxidant activities on rats.
TLDR
Evaluation of continuous heat extracted fraction of Moringa oleifera leaves for antioxidant, wound healing and anti- inflammatory activity in albino wistar rats revealed that the anti-inflammatory activity possibly attribute to its free radical scavenging property.
Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice, and their modification by anticonvulsants.
The patterns of maximal seizures evoked in mice by the intravenous injection of 38 mgm./kgm. Metrazol and by supramaximal electroshock have been compared. In addition, eight clinically useful
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
TLDR
The results suggest that the specificity of experimental models of epilepsy used in the evaluation of potential antiepileptic drugs is primarily due to the intensity rather than the nature of the stimulus used or the kind of seizure component evoked.
Antiepileptic Drug Development: II. Anticonvulsant Drug Screening
TLDR
The Anticonvulsant Screening Project has evaluated the activity of 1,495 experimental compounds accessioned in the first 2 years, and preliminary data show that 430 of these compounds have good anticonVulsant activity.
Effects of Novel 6-Desfluoroquinolones and Classic Quinolones on Pentylenetetrazole-Induced Seizures in Mice
TLDR
The relationship between the chemical structure and the proconvulsant activity of 6-desfluoroquinolone derivatives was studied and it was observed that, in terms of toxicity to the central nervous system (CNS), the C-6 substituent also appears to play an important role.
Possible mechanism of anticonvulsant effect of ketamine in mice.
TLDR
The results suggest that besides its known antagonistic effect on NMDA channel, other neurotransmitter systems i.e. sigma, GABAA-BZD-chloride channel complex and GABAB receptors may also be involved in the anti-MES action of ketamine.
...
1
2
3
...