ANTI-TUMOR NECROSIS FACTOR-α ACTIVITY OF DIOSGENIN IN NAEGLERIA FOWLERI LYSATE-INDUCED HUMAN MONOCYTE U 937-DERIVED MACROPHAGES

@inproceedings{Rabablert2016ANTITUMORNF,
  title={ANTI-TUMOR NECROSIS FACTOR-α ACTIVITY OF DIOSGENIN IN NAEGLERIA FOWLERI LYSATE-INDUCED HUMAN MONOCYTE U 937-DERIVED MACROPHAGES},
  author={Jundee Rabablert and Supawan Kaewchiangwang and Supathra Tiewcharoen and Prasert Auewarakul and Sittiruk Roytrakul and Tub Rungreung and Virach Junnu},
  year={2016}
}
Free-living Naegleria fowleri amoebae cause fatal primary amoebic meningoencephalitis in humans. Additionally, N. fowleri lysate induces strong cytopathic effects and proinflammatory cytokines in microglial cells. Our previous study revealed that diosgenin has an anti-amoebic activity against N. fowleri trophozoites and less toxicity in mammalian cells than amphotericin B. In the present study, we investigated the effect of diosgenin on the gene expression of proinflammatory cytokines tumor… CONTINUE READING

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