Corpus ID: 59496153


  author={A. Goel},
  • A. Goel
  • Published 2009
  • Materials Science
Summary The gum of Boswellia serrata has been widely used in ayurvedic and traditional system of medicine for the treatment of inflammation. 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent pentacyclic triterpenic acid present in gum of Boswellia serrata for anti-inflammatory and antiarthritic activity. The objective of the present investigation was to study the anti-inflammatory activity of nanogel formulation of AKBA against carrageenan induced rat paw edema. Topical gel for in… Expand

Figures and Tables from this paper

Topical Nanoemmigel Formulation of Boswellia serrata
Boswellia serrata was formulated as topical analgesic and antiinflammatory nanoemmigel, which is a combination of a nanoemulsion and a nanomicellar system in a gel base. Nanoemulsion was formulatedExpand
Chromatographic methods used for characterization of boswellic acids
Utilization of natural herbs and their drug products have been extensively increases worldwide because of lesser side effects of natural origin based products in contrast with synthetic products GumExpand
Polymers in topical delivery of anti-psoriatic medications and other topical agents in overcoming the barriers of conventional treatment strategies
The current investigation of suitable polymer would assist in brushing the authors' expertise to optimize the advantages of a wide spectrum of polymers to fulfill the topical targeting of psoriasis. Expand
Overview of nanogel and its applications
Nanogel have emerged as a versatile drug delivery system for encapsulation of guest molecules. A nanoparticle which is composed of hydrophilic polymer network known as Nanogel having range fromExpand
Current trends and concepts in the design and development of nanogel carrier systems
Nanotechnology, a relatively novel technique, has much potential in smart drug delivery. Development of novel nanosized particulate drug delivery systems (DDS) may help in disease prevention,Expand


Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring triterpenoids, beta-boswellic acid and its structural related derivatives, has been usedExpand
Analgesic activity of acetyl-11-keto-beta-boswellic acid, a 5-lipoxygenase-enzyme inhibitor
Acetyl-11-keto-beta-boswellic acid (AKBA) is one of the four major pentacyclic triterpenic acids present in the acidic extract of the Boswellia serrata gum resin that is used for a variety ofExpand
Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.
It is concluded that water extract of Boswellia serrata possesses strong hypocholesterolemic property along with increase in serum HDL and inhibits the LPS induced NO production by the activated rat peritoneal macrophages and show hepato-protective and reno-Protective property. Expand
Metabolism of Boswellic Acids in Vitro and in Vivo
This study indicates that the efficacy of B. serrata extract may be enhanced by increasing the bioavailability of AKBA, the main active ingredients of boswellic acids, which is not deacetylated to KBA. Expand
Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.
A synergistic effect was observed in chronic inflammatory conditions when two chemical entities were administered in combination in preclinical study of boswellic acids and glucosamine in rats. Expand
Pharmacokinetic study of 11-Keto beta-Boswellic acid.
Elimination half life of nearly six hours suggests that the drug needs to be given orally at the interval of six hours to achieve steady state, and BSE is a safe drug and well tolerated on oral administration. Expand
Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis.
The effect of boswellic acids on bovine serum albumin (BSA)-induced arthritis in rabbits was studied and the leucocyte-inhibitory activity of bos wellic acids was not due to its cytotoxic effect. Expand
Boswellic acids in chronic inflammatory diseases.
  • H. Ammon
  • Chemistry, Medicine
  • Planta medica
  • 2006
Clinical studies suggest efficacy in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma using Oleogum resins from BOSWELLIA species. Expand
Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the5-LO or blocking its translocation. Expand
Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.
Four major triterpene acids, isolated from the gum resin of Boswellia serrata, inhibited the synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner and the effect of 4 on DNA synthesis was found to be irreversible. Expand