• Corpus ID: 59496153

ANTI-INFLAMMATORY ACTIVITY OF NANOGEL FORMULATION OF 3-ACETYL- 11-KETO-β-BOSWELLIC ACID

@inproceedings{Goel2009ANTIINFLAMMATORYAO,
  title={ANTI-INFLAMMATORY ACTIVITY OF NANOGEL FORMULATION OF 3-ACETYL- 11-KETO-$\beta$-BOSWELLIC ACID},
  author={Amit Goel},
  year={2009}
}
Summary The gum of Boswellia serrata has been widely used in ayurvedic and traditional system of medicine for the treatment of inflammation. 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent pentacyclic triterpenic acid present in gum of Boswellia serrata for anti-inflammatory and antiarthritic activity. The objective of the present investigation was to study the anti-inflammatory activity of nanogel formulation of AKBA against carrageenan induced rat paw edema. Topical gel for in… 
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29 References

Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.

Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring triterpenoids, beta-boswellic acid and its structural related derivatives, has been used…

Analgesic activity of acetyl-11-keto-beta-boswellic acid, a 5-lipoxygenase-enzyme inhibitor

On the basis of the possible role of the leukotrienes in sensitization and provocation of nociceptors, the study was undertaken to assess the analgesic activity of AKBA (5-LOX inhibitor) in different pain models.

Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property.

It is concluded that water extract of Boswellia serrata possesses strong hypocholesterolemic property along with increase in serum HDL and inhibits the LPS induced NO production by the activated rat peritoneal macrophages and show hepato-protective and reno-Protective property.

Metabolism of Boswellic Acids in Vitro and in Vivo

This study indicates that the efficacy of B. serrata extract may be enhanced by increasing the bioavailability of AKBA, the main active ingredients of boswellic acids, which is not deacetylated to KBA.

Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.

Pharmacokinetic study of 11-Keto beta-Boswellic acid.

Elimination half life of nearly six hours suggests that the drug needs to be given orally at the interval of six hours to achieve steady state, and BSE is a safe drug and well tolerated on oral administration.

Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis.

Boswellic acids in chronic inflammatory diseases.

Clinical studies suggest efficacy in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma using Oleogum resins from BOSWELLIA species.

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the5-LO or blocking its translocation.

Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.

Four major triterpene acids, isolated from the gum resin of Boswellia serrata, inhibited the synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner and the effect of 4 on DNA synthesis was found to be irreversible.