• Corpus ID: 54722327

ANTI-CANCER ACTIVITY OF RUTIN ENCAPSULATED IN LOW METHOXYL PECTIN BEADS

@inproceedings{Jantrawut2014ANTICANCERAO,
  title={ANTI-CANCER ACTIVITY OF RUTIN ENCAPSULATED IN LOW METHOXYL PECTIN BEADS},
  author={Pensak Jantrawut and Hiroyuki Akazawa},
  year={2014}
}

• P. Jantrawut, H. Akazawa
• Published 2014
• Biology, Medicine

Objective: This study was investigating the anti-cancer activity of rutin encapsulated in non-amidated low methoxyl pectin bead in various formulations with or without sorbitol and/or sodium bicarbonate (NaHCO3). Methods: The rutin beads formulations including 3NA (3% Non-amidated LMP), 3NA15Sor (3% Non-amidated LMP with 15% Sorbitol), 3NA1Bica (3% Non-amidated LMP with 1% NaHCO3) and 3NA15Sor1Bica (3% Non-amidated LMP with 15% Sorbitol and 1% NaHCO3) were prepared and the in vitro anti-cancer activities in 3 human cancer cell lines were investigated. Results: All beads were oblong or spherical shape with around 600 µm size. 3NA15Sor1Bica rutin bead composing both sorbitol and NaHCO3 exhibited higher cytotoxic activity with cancer cell viability were 51.41 ± 7.01 and 55.12 ± 3.96% on HT-29 and KB cells, respectively. There was no significant different (p>0.05) of cell viability between all bead formulation for HepG2 cells. Conclusion: These results confirmed that encapsulation of rutin in pectin beads exhibited their anti-cancer activity and can be applied for further human cancer treatment formulation.