ANRIL: A Regulator of VEGF in Diabetic Retinopathy.

  title={ANRIL: A Regulator of VEGF in Diabetic Retinopathy.},
  author={Anu Alice Thomas and Biao Feng and Subrata Chakrabarti},
  journal={Investigative ophthalmology & visual science},
  volume={58 1},
Purpose Long noncoding RNAs (lncRNAs) previously thought to be "dark matter" of the genome, play key roles in various biological processes. The lncRNA ANRIL is located at a genetic susceptibility locus for coronary artery diseases and type 2 diabetes. We examined the role of ANRIL in diabetic retinopathy, through study of its regulation of VEGF both in vitro and in vivo. Methods Human retinal endothelial cells (HRECs) were subjected to incubation in high glucose to mimic diabetes. ANRIL… CONTINUE READING
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