ANP-induced signaling cascade and its implications in renal pathophysiology.

  title={ANP-induced signaling cascade and its implications in renal pathophysiology.},
  author={Franziska Theilig and Qingyu Wu},
  journal={American journal of physiology. Renal physiology},
  volume={308 10},
The balance between vasoconstrictor/sodium-retaining and vasodilator/natriuretic systems is essential for maintaining body fluid and electrolyte homeostasis. Natriuretic peptides, such as atrial natriuretic peptide (ANP), belong to the vasodilator/natriuretic system. ANP is produced by the conversion of pro-ANP into ANP, which is achieved by a proteolytical cleavage executed by corin. In the kidney, ANP binds to the natriuretic peptide receptor-A (NPR-A) and enhances its guanylyl cyclase… CONTINUE READING
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