ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta.

@article{Fedorova2006ANPDM,
  title={ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta.},
  author={Olga V. Fedorova and Natalia Ivanovna Agalakova and Christopher H. Morrell and Edward G. Lakatta and Alexei Y. Bagrov},
  journal={Hypertension},
  year={2006},
  volume={48 6},
  pages={1160-8}
}
NaCl loading and plasma volume expansion stimulate 2 natriuretic systems, vasoconstrictor, digitalis-like Na/K-ATPase inhibitors and vasorelaxant ANP peptides. Several hormones, including ANP, regulate activity of the Na/K-ATPase by modulation of its phosphorylation state. We studied effects of ANP on Na/K-ATPase phosphorylation and inhibition by an endogenous sodium pump ligand, marinobufagenin, in the aorta and renal medulla from male Sprague-Dawley rats. Marinobufagenin dose-dependently… CONTINUE READING