ANOVA-Like Differential Expression (ALDEx) Analysis for Mixed Population RNA-Seq

@inproceedings{Fernandes2013ANOVALikeDE,
  title={ANOVA-Like Differential Expression (ALDEx) Analysis for Mixed Population RNA-Seq},
  author={Andrew Dellano Fernandes and Jean Megan E Macklaim and Thomas Linn and Gregor Reid and Gregory B. Gloor},
  booktitle={PloS one},
  year={2013}
}
Experimental variance is a major challenge when dealing with high-throughput sequencing data. This variance has several sources: sampling replication, technical replication, variability within biological conditions, and variability between biological conditions. The high per-sample cost of RNA-Seq often precludes the large number of experiments needed to partition observed variance into these categories as per standard ANOVA models. We show that the partitioning of within-condition to between… CONTINUE READING

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