ANN-Spec: a method for discovering transcription factor binding sites with improved specificity.

@article{Workman2000ANNSpecAM,
  title={ANN-Spec: a method for discovering transcription factor binding sites with improved specificity.},
  author={Christopher T. Workman and Gary D. Stormo},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2000},
  pages={467-78}
}
This work describes ANN-Spec, a machine learning algorithm and its application to discovering un-gapped patterns in DNA sequence. The approach makes use of an Artificial Neural Network and a Gibbs sampling method to define the Specificity of a DNA-binding protein. ANN-Spec searches for the parameters of a simple network (or weight matrix) that will maximize the specificity for binding sequences of a positive set compared to a background sequence set. Binding sites in the positive data set are… CONTINUE READING
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  • G. D. Stormo, G. W. Hartzell
  • Proc . Natl . Acad . Sci . USA
  • 1989

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