Corpus ID: 14423218

ANIMAL MODELS FOR HUNTINGTON'S DISEASES: A REVIEW

@inproceedings{Manisha2012ANIMALMF,
  title={ANIMAL MODELS FOR HUNTINGTON'S DISEASES: A REVIEW},
  author={S. Manisha and K. Sunil and S. Nidhi},
  year={2012}
}
Huntington's disease (HD) is an inherited autosomal, progressive neurodegenerative disorder associated with involuntary abnormal movements (chorea), cognitive impairments and psychiatric disturbances. HD is caused by an abnormal expansion of a CAG region located in exon 1 o f the g ene encoding the huntingtin protein (Htt) and is the causative factor in the pathogenesis of HD Animal models of HD have provided insight into disease pathology and the outcomes of thera - peutic strategies. Earlier… Expand

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