ANGIOTENSIN‐CONVERTING ENZYME IN MACRO‐AND MICROVESSELS OF THE RAT

@article{Jandeleit1991ANGIOTENSINCONVERTINGEI,
  title={ANGIOTENSIN‐CONVERTING ENZYME IN MACRO‐AND MICROVESSELS OF THE RAT},
  author={Karin Jandeleit and Bruce Jackson and Rose Perich and Donna Paxton and Colin I. Johnston},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={1991},
  volume={18}
}
1. Angiotensin‐converting enzyme (ACE) was measured in the aorta, cerebral and mesenteric microvessels of Wistar‐Kyoto rats using a specific radioligand assay. 
MESENTERIC RESISTANCE AND BRAIN MICROVASCULAR ANGIOTENSIN‐CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT
1. Angiotensin‐converting enzyme (ACE) concentration was measured in mesenteric and brain microvessels from spontaneously hypertensive rats (SHR) and compared with normotensive controls using a
MESENTERIC VASCULAR ANGIOTENSIN‐CONVERTING ENZYME IS INCREASED IN EXPERIMENTAL DIABETES MELLITUS
1. Diabetes mellitus was induced by streptozotocin in male Wistar rats, and angiotensin‐converting enzyme measured in plasma and mesenteric vessels 3 weeks later.
THE TISSUE RENIN‐ANGIOTENSIN SYSTEM AND ITS FUNCTIONAL ROLE
1. The components of the renin‐angiotensin system exist in many cardiovascular tissues (heart vessels, kidneys, adrenal glands).
Characterisation of angiotensin converting enzyme from different rat vascular beds.
TLDR
In vivo, the enzyme inhibition in plasma, mesenteric and brain vessels measured by enzyme kinetic and radioligand binding assay were well correlated, and there was a similar degree of inhibition between different vessels and tissues measured by in vitro autoradiography.
The renin-angiotensin system in the endocrine pancreas.
  • P. Carlsson
  • Biology, Medicine
    JOP : Journal of the pancreas
  • 2001
TLDR
Alterations in the systemic renin-angiotensin system and an increased vascular sensitivity for its components have been observed in diabetes mellitus and hypertension, and whether changes occur also in the pancreatic islet renIn-angiotsin system during these conditions remains unknown.
Angiotensin Receptor Subtypes and Cerebral Blood Flow
TLDR
The brain receives approximately 15% of the cardiac output to maintain a blood flow rate of around 50 ml/100 g tissue per min, which means cerebral blood flow can be maintained even if one of the vascular territories fails.
Angiotensin II contributes to cerebral vasodilatation during hypoxia in the rabbit.
TLDR
The findings suggest that endogenous release of angiotensin II contributes to the increase in CBF during hypoxia, and that hypercapnia increased CBF similarly in the absence and presence of saralasin.
Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas.
TLDR
Of particular interest in this context are the recent epidemiological data showing that administration of angiotensin-converting enzyme inhibitors appears to be protective against the development of diabetes in hypertensive patients.
Angiotensin Receptors

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CHARACTERIZATION OF ANGIOTENSIN CONVERTING ENZYME FROM RAT TISSUE BY RADIO‐INHIBITOR BINDING STUDIES
1. Angiotensin converting enzyme (ACE) derived from rat lung, aorta, epididymus, brain, kidney and plasma was characterized by radio‐inhibitor (125I‐MK351A) binding studies. Under optimal binding
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Fluorescein-labeled antibody to rabbit pulmonary angiotensin-converting enzyme localized in the vascular endothelium of rabbit lung, liver, adrenal cortex, pancreas, kidney, and spleen demonstrated immunoreactivity.
Angiotensin Converting Enzyme Activity in Brain Microvessels of Rats
TLDR
ACE activity is measured in brain microvessels obtained from 13-week-old spontaneously hypertensive rats (SHR), Wistar-Kyoto rats, and SHR of the same age under antihypertensive therapy to clarify the effect of hypertension on the brainmicrovessels.
Properties of Angiotensin‐Converting Enzyme in Intact Cerebral Microvessels
TLDR
The ability to measure ACE activity of the microvessels in vitro provides a unique opportunity to study the properties of the enzyme in intact cerebrovascular endothelial cells.
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The results indicate that the elevation of vascular ACE activity may play an important role in the maintenance of high blood pressure and may result in hypotension in response to ACE inhibitors in the chronic stage of 1-K,1C hypertension.
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The results suggest that the vascular renin-angiotensin system plays an important role in the maintenance of two-kidney, one clip hypertension.
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Evidence is provided that the renin-angiotensin system is important in acute blood pressure regulation during sodium depletion, anesthesia, and hemorrhage, as well as in the initiation of renovascular hypertension and in the development of the syndrome of congestive heart failure.
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