ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species.

@article{Zhang2004ANGIS,
  title={ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species.},
  author={Zhong Rong Zhang and Kristie Rhinehart and Whaseon Lee Kwon and Edward J. Weinman and Thomas L. Pallone},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 2},
  pages={
          H773-81
        }
}
ANG II constricts descending vasa recta (DVR) through Ca(2+) signaling in pericytes. We examined the role of PKC DVR pericytes isolated from the rat renal outer medulla. The PKC blocker staurosporine (10 microM) eliminated ANG II (10 nM)-induced vasoconstriction, inhibited pericyte cytoplasmic Ca(2+) concentration ([Ca(2+)](cyt)) elevation, and blocked Mn(2+) influx into the cytoplasm. Activation of PKC by either 1,2-dioctanoyl-sn-glycerol (10 microM) or phorbol 12,13-dibutyrate (PDBu; 1 microM… CONTINUE READING

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