ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

@article{Huang2014ANGIP,
  title={ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation},
  author={Chiung-Yu Huang and W-W Kuo and Y-L Yeh and T-J Ho and Jin-Yuarn Lin and D-Y Lin and Chih-Hsun Chu and F A Tsai and C-H Tsai},
  journal={Cell Death and Differentiation},
  year={2014},
  volume={21},
  pages={1262-1274}
}
Hypertension-induced cardiac hypertrophy and apoptosis are major characteristics of early-stage heart failure. Our previous studies found that the activation of insulin-like growth factor receptor II (IGF-IIR) signaling was critical for hypertensive angiotensin II (ANG II)-induced cardiomyocyte apoptosis. However, the detailed mechanism by which ANG II regulates IGF-IIR in heart cells remains elusive. In this study, we found that ANG II activated its downstream kinase JNK to increase IGF-IIR… CONTINUE READING
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