ANG II and baroreflex function in rabbits with CHF and lesions of the area postrema.

@article{Liu1999ANGIA,
  title={ANG II and baroreflex function in rabbits with CHF and lesions of the area postrema.},
  author={Jinjin Liu and Hiroshi Murakami and Max G Sanderford and Vernon S Bishop and Irving H. Zucker},
  journal={The American journal of physiology},
  year={1999},
  volume={277 1},
  pages={
          H342-50
        }
}
Blockade of the angiotensin II (ANG II) type 1 receptor (AT(1)) has been shown to restore baroreflex sensitivity in rats and rabbits with experimental chronic heart failure (CHF). Because the modulation of baroreflex function in response to ANG II is mediated in part by AT(1) receptors located in the area postrema, we hypothesized that lesions of the area postrema would prevent the enhancement in baroreflex function in response to AT(1)-receptor blockade in rabbits with pacing-induced CHF… CONTINUE READING

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