ANDROGEN METABOLISM AND SPECIFIC 5α-DIHYDROTESTOSTERONE (DHT) RECEPTORS IN HUMAN AMNIOTIC FLUID FIBROBLASTS

@article{Sultan1981ANDROGENMA,
  title={ANDROGEN METABOLISM AND SPECIFIC 5α-DIHYDROTESTOSTERONE (DHT) RECEPTORS IN HUMAN AMNIOTIC FLUID FIBROBLASTS},
  author={Ch Sultan and Jane M. Emberger and Bernard Descomps and A Crastes de Paulet},
  journal={Pediatric Research},
  year={1981},
  volume={15},
  pages={1548}
}
This study was designed to find out whether human amniotic fluid cells have steroid 5 α-reductase activity and specific intracellular androgen receptors, and whether they could be used for antenatal diagnosis of male pseudohermaphroditism due to androgen resistance. "Fibroblast-like" cells cultures were raised from 12 amniotic fluids collected at mid-gestation. Specific receptor bound-DHT in the cell lysate was measured by a charcoal adsorption method. The binding specificity of the DHT… CONTINUE READING