ANCHOR: a web server and database for analysis of protein–protein interaction binding pockets for drug discovery

@inproceedings{Meireles2010ANCHORAW,
  title={ANCHOR: a web server and database for analysis of protein–protein interaction binding pockets for drug discovery},
  author={Lidio M. C. Meireles and Alexander S. D{\"o}mling and Carlos J. Camacho},
  booktitle={Nucleic Acids Research},
  year={2010}
}
ANCHOR is a web-based tool whose aim is to facilitate the analysis of protein-protein interfaces with regard to its suitability for small molecule drug design. To this end, ANCHOR exploits the so-called anchor residues, i.e. amino acid side-chains deeply buried at protein-protein interfaces, to indicate possible druggable pockets to be targeted by small molecules. For a given protein-protein complex submitted by the user, ANCHOR calculates the change in solvent accessible surface area… CONTINUE READING
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