ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.

@article{Morris2011ANCAassociatedVI,
  title={ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.},
  author={Heather D Morris and Matthew David Morgan and Alice M. Wood and Stuart William Smith and Ugo I. Ekeowa and Kristine Herrmann and Julia Ulrike Holle and Lo{\"i}c Guillevin and David A. Lomas and Javier Serrano P{\'e}rez and Charles Dickson Pusey and Alan David Salama and R Stockley and Stefan Wieczorek and Amy-Jayne McKnight and Alexander Peter Maxwell and Elena Miranda and Jack Williams and Caroline O. S. Savage and Lorraine Harper},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 10},
  pages={1851-6}
}
BACKGROUND Small studies have linked α1 antitrypsin (α1AT) deficiency to patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). OBJECTIVE To test the validity and the mechanism of this association between α1AT and AAV. METHODS The distribution of α1AT deficiency alleles Z and S was compared between 856 White Europeans with AAV and 1505 geographic and ethnically matched healthy controls. Genotyping was performed by allelic discrimination assay. RESULTS were… CONTINUE READING

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