ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. II. COMPARATIVE PHARMACOLOGICAL STUDIES OF ACETYLCHOLINE, ITS THIO AND SELENO ANALOGS, AND THEIR HYDROLYSIS PRODUCTS.
@article{Scott1964ANALOGSOP, title={ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. II. COMPARATIVE PHARMACOLOGICAL STUDIES OF ACETYLCHOLINE, ITS THIO AND SELENO ANALOGS, AND THEIR HYDROLYSIS PRODUCTS.}, author={Kenneth A. Scott and Henry G. Mautner}, journal={Biochemical pharmacology}, year={1964}, volume={13}, pages={ 907-20 } }
26 Citations
Sulfur and selenium isologs related to acetylcholine and choline. IX. Further comparative studies of the pharmacological effects of acetylcholine and its thio and seleno analogs and their hydrolysis products.
- Chemistry, BiologyBiochemical pharmacology
- 1967
Muscarinic and nicotinic activities of the novel acetylcholine analog acetylselenonium choline.
- Chemistry, BiologyLife sciences
- 1992
Relationship between acetylcholine and local anesthetics.
- Biology, ChemistryBiochimica et biophysica acta
- 1965
FINE STRUCTURAL LOCALIZATION OF ACETYLCHOLINESTERASE USING ACETYL-β-METHYLTHIOCHOLINE AND ACETYLSELENOCHOLINE AS SUBSTRATES
- Biology, ChemistryThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- 1969
Acetyl-β-methylthiocho1ine and acetylselenocholine were used as substrates for fine structural demonstration of acetylcholinesterase activity and were compared with acetylthiocholine and proved to be the most specific for acetyl- β- methylthiocoline in the cytochemical system used.
The actions of some muscarinic and nicotinic agonists on the Retzius cells of the leech.
- BiologyComparative and general pharmacology
- 1971
Sulfur and selenium compounds related to acetylcholine and choline. VI. Effects of homocholine derivatives on the electroplax preparation.
- Chemistry, BiologyBiochemical pharmacology
- 1966
Sulfur and selenium isologs related to acetycholine. and choline IV. Activity in the electroplax preparation.
- Chemistry, BiologyBiochemical pharmacology
- 1966
Cholinergic Anionic Receptors II: Examination of a Conformationally Restricted Analog of Acetylcholine
- Biology, Chemistry
- 1965
The hydrolysis of acetylcholine consists of a number of stages, including the formation of an enzyme–substrate complex and the subsequent dissociation of this complex yielding the free enzyme,…
Isologous Oxygen, Sulfur, and Selenium Compounds as Probes of Acetylcholine Receptors
- Chemistry, BiologyThe Journal of general physiology
- 1969
Experiments with sulfur and selenium isologs of acetylcholine, choline, and local anesthetics suggest that the active sites of receptors of the electroplax and of electric eelacetylcholinesterase are different, but are compatible with the postulate that acetyl choline receptors of axonal and synaptic excitable membranes are similar.
Structure Activity Relationships of some Muscarinic Agonists: a Reply to Shefter and Triggle
- BiologyNature
- 1970
The criticism by Shefter and Triggle of the model2 for the interaction of acetylcholine, (CH3)3N+-CH2CH2OCOCH3, with muscarinic receptors is that it does not explain the mus carinic potency of some analogues of acetylene, but the model does account for the activity of these compounds.
References
SHOWING 1-10 OF 25 REFERENCES
The effect of certain choline esters on the chemoceptor activity in the carotid body.
- Biology, ChemistryActa physiologica Scandinavica
- 1954
The view that acetylcholine or related substances are involved in the initiation of the chemoceptive discharge from the carotid body is supported.
Further aspects of stereospecificity in interaction of polyfunctional amine derivatives with bio-logical receptors.
- Chemistry, BiologyArchives of biochemistry and biophysics
- 1962
Hemicholinium antagonism by choline analogues.
- Biology, ChemistryThe Journal of pharmacology and experimental therapeutics
- 1959
A series of choline analogues and esters of choline have been evalulated for their ability to antagonize a neuromuscular blockade produced by the hemicholinium (HC-3). The structure of choline…
STUDIES ON THE CHEMICAL BASIS FOR CHOLINOMIMETIC AND CHOLINOLYTIC ACTIVITY: PART I. THE SYNTHESIS AND CONFIGURATION OF QUATERNARY SALTS IN THE 1,3-DIOXOLANE AND OXAZOLINE SERIES
- Chemistry
- 1962
Structure activity relationships in the muscarine and the quaternary 1,3-dioxolane (Fourneau series) series are briefly discussed. The most active member of the latter series…
Choline Antimetabolites. Studies with Intestinal Muscle
- BiologyProceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
- 1956
Choline-like and anticholine activities of a series of compounds structurally related to choline have been determined using segments of rabbit ileum using segment-by-segment analysis.
Spectrophotometric methods for determination of cholinesterase activity.
- Biology, ChemistryClinica chimica acta; international journal of clinical chemistry
- 1957
A new and rapid colorimetric determination of acetylcholinesterase activity.
- Biology, ChemistryBiochemical pharmacology
- 1961
A new, general electrochemical method of determining enzyme kinetics. Kinetics of the enzymic hydrolysis of thiocholine iodide esters.
- BiologyAnalytical biochemistry
- 1963
Darstellung und Umsetzungen von Mercaptomethyl‐und β‐Mercaptoäthyl‐ammoniumsalzen
- Chemistry
- 1960
Chlormethyl-acetyl-sulfid bildet mit Trimethylamin Trimethyl-acetylmercaptomethyl-ammoniumchlorid (I), mit Pyridin Acetylmercaptomethyl-pyridinium-chlorid (VI), die mit methanol. Perchlorsaure in die…