ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. II. COMPARATIVE PHARMACOLOGICAL STUDIES OF ACETYLCHOLINE, ITS THIO AND SELENO ANALOGS, AND THEIR HYDROLYSIS PRODUCTS.

@article{Scott1964ANALOGSOP,
  title={ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS. II. COMPARATIVE PHARMACOLOGICAL STUDIES OF ACETYLCHOLINE, ITS THIO AND SELENO ANALOGS, AND THEIR HYDROLYSIS PRODUCTS.},
  author={Kenneth A. Scott and Henry G. Mautner},
  journal={Biochemical pharmacology},
  year={1964},
  volume={13},
  pages={
          907-20
        }
}
26 Citations
Relationship between acetylcholine and local anesthetics.
  • E. Bartels
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 1965
FINE STRUCTURAL LOCALIZATION OF ACETYLCHOLINESTERASE USING ACETYL-β-METHYLTHIOCHOLINE AND ACETYLSELENOCHOLINE AS SUBSTRATES
  • A. Kokko, H. Mautner, R. Barrnett
  • Biology, Chemistry
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1969
TLDR
Acetyl-β-methylthiocho1ine and acetylselenocholine were used as substrates for fine structural demonstration of acetylcholinesterase activity and were compared with acetylthiocholine and proved to be the most specific for acetyl- β- methylthiocoline in the cytochemical system used.
Cholinergic Anionic Receptors II: Examination of a Conformationally Restricted Analog of Acetylcholine
The hydrolysis of acetylcholine consists of a number of stages, including the formation of an enzyme–substrate complex and the subsequent dissociation of this complex yielding the free enzyme,
Isologous Oxygen, Sulfur, and Selenium Compounds as Probes of Acetylcholine Receptors
  • H. Mautner
  • Chemistry, Biology
    The Journal of general physiology
  • 1969
TLDR
Experiments with sulfur and selenium isologs of acetylcholine, choline, and local anesthetics suggest that the active sites of receptors of the electroplax and of electric eelacetylcholinesterase are different, but are compatible with the postulate that acetyl choline receptors of axonal and synaptic excitable membranes are similar.
Structure Activity Relationships of some Muscarinic Agonists: a Reply to Shefter and Triggle
TLDR
The criticism by Shefter and Triggle of the model2 for the interaction of acetylcholine, (CH3)3N+-CH2CH2OCOCH3, with muscarinic receptors is that it does not explain the mus carinic potency of some analogues of acetylene, but the model does account for the activity of these compounds.
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References

SHOWING 1-10 OF 25 REFERENCES
The effect of certain choline esters on the chemoceptor activity in the carotid body.
TLDR
The view that acetylcholine or related substances are involved in the initiation of the chemoceptive discharge from the carotid body is supported.
Hemicholinium antagonism by choline analogues.
  • N. Reitzel, J. P. Long
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1959
A series of choline analogues and esters of choline have been evalulated for their ability to antagonize a neuromuscular blockade produced by the hemicholinium (HC-3). The structure of choline
STUDIES ON THE CHEMICAL BASIS FOR CHOLINOMIMETIC AND CHOLINOLYTIC ACTIVITY: PART I. THE SYNTHESIS AND CONFIGURATION OF QUATERNARY SALTS IN THE 1,3-DIOXOLANE AND OXAZOLINE SERIES
Structure activity relationships in the muscarine and the quaternary 1,3-dioxolane (Fourneau series) series are briefly discussed. The most active member of the latter series
Choline Antimetabolites. Studies with Intestinal Muscle
  • I. Wells, S. Mallov
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1956
TLDR
Choline-like and anticholine activities of a series of compounds structurally related to choline have been determined using segments of rabbit ileum using segment-by-segment analysis.
Spectrophotometric methods for determination of cholinesterase activity.
  • E. Gal, E. Roth
  • Biology, Chemistry
    Clinica chimica acta; international journal of clinical chemistry
  • 1957
Darstellung und Umsetzungen von Mercaptomethyl‐und β‐Mercaptoäthyl‐ammoniumsalzen
Chlormethyl-acetyl-sulfid bildet mit Trimethylamin Trimethyl-acetylmercaptomethyl-ammoniumchlorid (I), mit Pyridin Acetylmercaptomethyl-pyridinium-chlorid (VI), die mit methanol. Perchlorsaure in die
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