ANAESTHETICS DEPRESS THE SENSITIVITY OF CORTICAL NEURONES TO l‐GLUTAMATE

@article{Richards1976ANAESTHETICSDT,
  title={ANAESTHETICS DEPRESS THE SENSITIVITY OF CORTICAL NEURONES TO l‐GLUTAMATE},
  author={C. D. Richards and J. C. Smaje},
  journal={British Journal of Pharmacology},
  year={1976},
  volume={58}
}
  • C. D. Richards, J. C. Smaje
  • Published 1976
  • Chemistry, Medicine
  • British Journal of Pharmacology
  • 1 The effects of general anaesthetics on the responses of neurones to iontophoretically applied l‐glutamate have been examined in slices of the guinea‐pig olfactory cortex in vitro. 2 Concentrations of pentobarbitone, ether, methoxyflurane, trichloroethylene and alphaxalone that are known to depress synaptic transmission in the prepiriform cortex also depressed the sensitivity of prepiriform neurones to l‐glutamate. 3 Halothane, in concentrations that depress synaptic transmission (< 1%) did… CONTINUE READING

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