Corpus ID: 212452164

AN IN SILICO STUDY OF NOVEL FLUOROQUINOLONES AS INHIBITORS OF DNA GYRASE OF STAPHYLOCOCCUS AUREUS

@article{Sabbagh2015ANIS,
  title={AN IN SILICO STUDY OF NOVEL FLUOROQUINOLONES AS INHIBITORS OF DNA GYRASE OF STAPHYLOCOCCUS AUREUS},
  author={Ghalia Sabbagh and Thanaa Murad},
  journal={International Journal of Pharmacy and Pharmaceutical Sciences},
  year={2015},
  volume={8},
  pages={67-75}
}
  • G. Sabbagh, T. Murad
  • Published 18 November 2015
  • Chemistry
  • International Journal of Pharmacy and Pharmaceutical Sciences
Objective: This study is an attempt to identifying an effective fluoroquinolones (FQ) s against STAPHYLOCOCCUS AUREUS (S. aureus) by in silico analysis of 150 (FQ) compounds using iGemDock v2.1 tool. Methods : Structure of DNA gyrase (2XCT) was retrieved from the Protein Data Bank (PDB) and the structures of (FQ) compounds were selected from literature survey of 400 novel compounds and the physical, chemical and molecular characteristics of each compound were obeyed for drug-relevant properties… Expand

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