AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking

@inproceedings{Gao2017AMPKSI,
  title={AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking},
  author={X Y Gao and Kai Yuan and Lu Cao and Wei Yan and Yi-xiao Luo and M. H. Jian and Jian-Feng Liu and Qin Fang and Ji-shi Wang and Ying Han and Jie Shi and Lin Lu},
  booktitle={Scientific Reports},
  year={2017}
}
Relapse to drug seeking can be caused by exposure to drug-associated cues, provoking drug craving even after prolonged abstinence. Recent studies demonstrated that AMP-activated protein kinase (AMPK) regulates neuronal morphology and membrane excitability in neurons. Here, we investigated the role of AMPK activity in the nucleus accumbens (NAc) in relapse to cocaine seeking. We found that exposure to drug-related cues reinstated cocaine-seeking behavior and increased AMPK and p70s6k… CONTINUE READING

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