AMPK regulates immunometabolism in sepsis

@article{Huang2018AMPKRI,
  title={AMPK regulates immunometabolism in sepsis},
  author={Jun Huang and Ke Qin Liu and Sha Zhu and Min Xie and Rui Kang and Lizhi Cao and Daolin Tang},
  journal={Brain, Behavior, and Immunity},
  year={2018},
  volume={72},
  pages={89-100}
}
Sepsis and septic shock remain challenging for intensive care units worldwide and have limited treatment options; therefore, identification of targetable key players in systemic inflammation and multiple organ failure is urgently needed. Here, we show that AMP-activated protein kinase (AMPK) is a negative regulator of bioenergetic reprogramming in immune cells and suppresses sepsis development in vivo. Mechanistically, AMPK deficiency increases pyruvate kinase isozyme M2 (PKM2)-dependent… Expand
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