AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation.

@article{Lieberthal2011AMPKPP,
  title={AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation.},
  author={Wilfred Lieberthal and Leiqing Zhang and Vimal Patel and Jerrold S. Levine},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={301 6},
  pages={
          F1177-92
        }
}
We examined the role of AMP-activated protein kinase (AMPK) in modulating the viability of cultured kidney proximal tubular cells subjected to metabolic stress induced by either dextrose deprivation, inhibition of glycolysis, or inhibition of mitochondrial respiration. We used BU.MPT cells, a conditionally immortalized kidney epithelial cell line derived from the proximal tubules of transgenic mice bearing a temperature-sensitive mutation of the simian virus 40 large-tumor antigen. All three… CONTINUE READING

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