AMPK promotes tolerance to Ras pathway inhibition by activating autophagy

Abstract

Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great promise in the clinic, but resistance remains a major challenge: 30% of tumors with pathway mutations do not respond to targeted inhibitors, and of the 70% that do respond, all eventually develop resistance. Before cancer cells acquire resistance, they respond… (More)
DOI: 10.1038/onc.2016.70

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